血型影響你的記憶力
時間：2014-09-15 09:41:56 來源：轉化醫(yī)學網 點擊：
AB是最常見的血型，占美國總人口的4％左右。研究發(fā)現(xiàn)，與其他血型的人相比，AB型血的人有82％的可能性發(fā)展有思維和記憶問題、老年癡呆癥。
該研究是一項大型研究，涉及超過30,000人，平均隨訪研究3.4年。這些人在研究開始時沒有記憶或思考功能問題，但在研究過程中，研究確定了495名參與者發(fā)生思維和記憶問題或認知障礙。
將上述這些人與587名沒有認知問題的人進行比較。結果發(fā)現(xiàn)AB型血的人在有認知損傷的人群中占到6％的比例，高于總人口4%的比例。
雖然研究著眼于血型和認知障礙風險的關系，但也有一些研究表明：某些因素如高血壓，高膽固醇和糖尿病，也會增加認知障礙和老年癡呆癥的風險。此外，血型也涉及到其他如中風等血管疾病，所以研究血型和大腦健康之間的聯(lián)系是至關重要的，目前還需要更多的研究來證實這些結果。
研究人員還研究了血液中因子VIII的濃度，VIII可幫助血液凝結。高含量的因子VIII與認知損害和癡呆風險較高有關。 在這項研究中，具有較高水平因子VIII的人比蛋白質水平較低的人，發(fā)生思維和記憶問題的可能性高出24％。而AB型血的人與其他血型的人相比，有較高平均水平的Ⅷ因子。
原文鏈接：
ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort
Kristine S. Alexander, PhD, MCR, Neil A. Zakai, MD, MSc, Sarah Gillett, PhD, Leslie A. McClure, PhD, Virginia Wadley, PhD, Fred Unverzagt, PhD and Mary Cushman, MD, MSc
Objective: To assess the relationships among ABO group, factor VIII (FVIII), and incident cognitive impairment in a large, prospective cohort study of black and white adults in the United States using a nested case-control design.
Methods: Incident cognitive impairment was defined using cognitive domain tests over a mean follow-up of 3.4 years. ABO blood group was measured by genotyping in a nested case-control sample of 495 cases with cognitive impairment and 587 controls.
Results: Those with blood group AB and those with higher FVIII had an increased risk of cognitive impairment, adjusting for age, race, region, and sex (respective odds ratios 1.82, 95% confidence interval [CI] 1.15–2.90; and 1.24, 95% CI 1.10–1.38 for 40 IU/dL higher FVIII). Mean FVIII was higher in those with blood type AB (142 IU/dL; 95% CI 119–165) compared with O (104 IU/dL; 95% CI 101–107), and FVIII mediated 18% of the association between AB group and incident cognitive impairment (95% CI for mediation ?30% to 68%).
Conclusions: Blood group AB and higher FVIII were associated with increased incidence of cognitive impairment in this prospective study. The association of blood group AB with incident cognitive impairment was not significantly mediated by FVIII levels.
該研究是一項大型研究，涉及超過30,000人，平均隨訪研究3.4年。這些人在研究開始時沒有記憶或思考功能問題，但在研究過程中，研究確定了495名參與者發(fā)生思維和記憶問題或認知障礙。
將上述這些人與587名沒有認知問題的人進行比較。結果發(fā)現(xiàn)AB型血的人在有認知損傷的人群中占到6％的比例，高于總人口4%的比例。
雖然研究著眼于血型和認知障礙風險的關系，但也有一些研究表明：某些因素如高血壓，高膽固醇和糖尿病，也會增加認知障礙和老年癡呆癥的風險。此外，血型也涉及到其他如中風等血管疾病，所以研究血型和大腦健康之間的聯(lián)系是至關重要的，目前還需要更多的研究來證實這些結果。
研究人員還研究了血液中因子VIII的濃度，VIII可幫助血液凝結。高含量的因子VIII與認知損害和癡呆風險較高有關。 在這項研究中，具有較高水平因子VIII的人比蛋白質水平較低的人，發(fā)生思維和記憶問題的可能性高出24％。而AB型血的人與其他血型的人相比，有較高平均水平的Ⅷ因子。
原文鏈接：
ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort
Kristine S. Alexander, PhD, MCR, Neil A. Zakai, MD, MSc, Sarah Gillett, PhD, Leslie A. McClure, PhD, Virginia Wadley, PhD, Fred Unverzagt, PhD and Mary Cushman, MD, MSc
Objective: To assess the relationships among ABO group, factor VIII (FVIII), and incident cognitive impairment in a large, prospective cohort study of black and white adults in the United States using a nested case-control design.
Methods: Incident cognitive impairment was defined using cognitive domain tests over a mean follow-up of 3.4 years. ABO blood group was measured by genotyping in a nested case-control sample of 495 cases with cognitive impairment and 587 controls.
Results: Those with blood group AB and those with higher FVIII had an increased risk of cognitive impairment, adjusting for age, race, region, and sex (respective odds ratios 1.82, 95% confidence interval [CI] 1.15–2.90; and 1.24, 95% CI 1.10–1.38 for 40 IU/dL higher FVIII). Mean FVIII was higher in those with blood type AB (142 IU/dL; 95% CI 119–165) compared with O (104 IU/dL; 95% CI 101–107), and FVIII mediated 18% of the association between AB group and incident cognitive impairment (95% CI for mediation ?30% to 68%).
Conclusions: Blood group AB and higher FVIII were associated with increased incidence of cognitive impairment in this prospective study. The association of blood group AB with incident cognitive impairment was not significantly mediated by FVIII levels.
